Synthesis, characterization, molecular modeling and investigation of biological activity of the novel Schiff base (E)-2-(((4-bromothiophen-2-yl)methylene)amino)-5-methylphenol

ЖСХ, т.65, №11, 2024, 135383

Received: March, 19, 2024
Revised: June, 24, 2024
Accepted for publication: July, 20, 2024
DOI 10.26902/JSC_id135383
EDN: FFFTZT
Views: 172

¹ Department of Chemistry, Faculty of Arts and Sciences, Ondokuz Mayıs University, Samsun, Turkey

² Department of Nutrition and Dietetics, Faculty of Health Sciences, Çankırı Karatekin University, Çankırı, Turkey

³ Department of Nanoscience and Nanotechnology, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur, Turkey

⁴ Department of Chemistry Technology, Afsin Vocational School, Kahramanmaraş Sütcü İmam University, Kahramanmaras, Turkey

⁵ Department of Chemistry, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur, Turkey

The novel Schiff base derivative (E)-2-(((4-bromothiophen-2-yl)methylene)amino)-5-methylphenol (HL) was synthesized and characterized via FTIR, elemental analysis, UV-Vis, ¹H NMR and ¹³C NMR techniques. Quantum chemical calculations were performed with the density functional theory at the B3LYP level with the 6-311++G(d,p) basis tuned in the gas phase of the isolated compounds in the ground state. The thermal properties of HL Schiff base were investigated via DTA/TGA/TG curves. The antibacterial activity of the HL Schiff base against ESBL E. coli and MRSA was investigated. In the disk diffusion test, the zone of inhibition was determined against MRSA while it was not determined against ESBL E. coli. In addition, different levels of antibacterial activity were observed against all bacteria in the broth microdilution test.

Keywords: Schiff bases, X-ray diffraction, density functional calculations, biological activity

Импакт-фактор 2023 1.2
Срок опубликования 4 мес

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