Synthesis, crystal structure and bioactivities of Schiff base
derived from paeonol and 1,4-bis(3-aminopropyl)piperazine
- Received: August, 16, 2024
- Revised: October, 17, 2024
- Accepted for publication: October, 17, 2024
- DOI 10.26902/JSC_id139311
- EDN: PVXLEW
- Views: 155
1 College of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, P. R. China
2 School of Medicine and Chemical Engineering, Lianyungang Technical College, Lianyungang, Jiangsu, P. R. China
A new Schiff base, paeonol-[1,4-bis(3-aminopropyl)piperazine], was synthesized for the first time by the condensation reaction of paeonol and 1,4-bis(3-aminopropyl)piperazine through solution method. The product was characterized by the methods of melting point, IR, UV-vis, fluorescence spectrum, 1H NMR, elemental and thermal analysis, and its crystal structure was analyzed by single crystal X-ray diffraction method, which indicated that it belongs to triclinic system, P–1 group, a = 6.836(14) Å, b = 7.729(17) Å, c = 12.28(3) Å, α = 87.25(2)°, β = 85.53(2)°, γ = 88.74(2)°. The antioxidant and in vitro
antibacterial activities of the product were investigated by DPPH method and
agar plate diffusion method, respectively. Moreover, the interaction of the
product with biomacromolecule DNA was studied by the electronic spectroscopy
and viscosity method.
Keywords: paeonol, 1,4-bis(3-aminopropyl)piperazine, Schiff base, characterization, synthesis, bioactivity
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