Synthesis, structures and urease inhibition studies of cobalt(II)
and copper(I) complexes with thiosemicarbazone ligands
- Received: October, 12, 2025
- Revised: October, 30, 2025
- Accepted for publication: November, 5, 2025
- DOI 10.26902/JSC_id159335
- EDN: JOGTBS
- Views: 100
College of Science and Technology, Ningbo University, Ningbo, P. R. China
New cobalt(II) and copper(I) complexes, [CoCl2(L1)2] (1) and [CuClL2(Ph3P)2]·CH3CN (2), where L1 = 1-(4-bromobenzylidene)thiosemicarbazide, L2 = 1-(2,4-dichlorobenzylidene)thiosemicarbazide, PPh3 = triphenylphosphine, were synthesized and characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The complexes were also tested for their urease inhibitory properties. The cobalt complex has strong activity (IC50 = 5.7 mM). Enzymatic kinetics research suggested that the cobalt complex is a noncompetitive urease inhibitor.
This is an excerpt of the article
DOI: 10.1134/S0022476626010075
This is an excerpt of the article
Synthesis, structures and urease inhibition studies of cobalt(II)
and copper(I) complexes with thiosemicarbazone ligands.
DOI: 10.1134/S0022476626010075
Keywords: cobalt complex, copper complex, crystal structure, urease inhibitor
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