Synthesis, crystal structure, and anti-gastric cancer activity
of a heterometallic coordination polymer
based on flexible 6,6′-dithiodinicotinic acid
- Received: August, 4, 2019
- Revised: September, 13, 2019
- Accepted for publication: September, 16, 2019
- DOI 10.26902/JSC_id57733
- Views: 589
1 Gastroenterology (Internal Medicine of Abdominal Tumors), Guangfu Cancer Hospital, Jinhua, Zhejiang, P. R. China
2 Cardiology Department, Jinhua Fifth Hospital, Jinhua, Zhejiang, P. R. China
3 Paediatrics Department, People's Hospital of Gansu Province, Lanzhou, Gansu, P. R. China
4 Digestive Endoscopy Center, Laishan Branch Hospital, Yuhuangding Hospital, Yantai, Shandong, P. R. China
A new bimetallic coordination polymer [In2Na(H2O)2(ddca)3](NO3)×4H2O (1, H2ddca = 6,6'-dithiodinicotinic acid) is produced via a hydrothermal reaction of In(NO3)3, H2ddca with NaOH as the pH modulator. Various characterization methods, such as thermogravimetric analysis (TGA), elemental analysis (EA), single crystal and powder X-ray diffraction measurements, are used. Furthermore, a process of sonochemistry with oleic acid at 453 K is used to produce nanoparticles of 1 (nano-1). In terms of the biological function of the synthesized complex, the real-time reverse transcription-polymerase chain reaction is carried out to explore the relative mRNA expression of miR-181 in MGC-803, BGC-823, and SGC-7901 gastric cancer cell lines, and the western blot is used to explore the protein expression of apoptotic protein Bcl-2.
Keywords: coordination polymer, bimetallic, nanostructure, anticancer activity
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Импакт-фактор 2024 1.4 |
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Срок опубликования 4 мес |
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XII Национальная кристаллохимическая конференция Апатиты, 4–12 июля 2026 г. |
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