Two Co(II) and Zn(II) coordination polymers: structural characterization and anticancer activity against nasopharyngeal carcinoma
- Received: February, 20, 2020
- Revised: April, 2, 2020
- Accepted for publication: April, 9, 2020
- DOI 10.26902/JSC_id61709
- Views: 174
1 Otolaryngology and Maxillofacial Surgery, People's Hospital of Wuwei City, Wuwei, Gansu, P. R. China
2 Integrated TCM and Western Medicine Department, People's Hospital of Wuwei City, Wuwei, Gansu, P. R. China
3 E.N.T. Department, People’s Hospital of Wuwei City, Wuwei, Gansu, P. R. China
By employing a mixed-ligand strategy, two new coordination polymers with the chemical formulae [Co(4-bptzh)(1,3-BDC)] (1) and [Zn(4-bptzp)(1,3-BDC)]n (2) are hydrothermally synthesized using two flexible bis(pyridyl-tetrazole) ligands (4-bptzh = 1,4-bis(5-(4-pyridyl)tetrazolyl)hexane, 4-bptzp = 1,4-bis(5-(4-pyridyl)tetrazolyl)propane) and 1,3-benzenedicarboxylic acid (1,3-H2BDC). Both complexes are characterized by single crystal X-ray diffraction along with the elemental analysis. Furthermore, the inhibitory effect of compounds 1 and 2
against CNE-1 nasopharyngeal cancer cells are evaluated in vitro. Firstly, the antiproliferation activity of compounds 1 and 2 against cancer cells
is assessed by the CCK-8 assay. Then, the cancer cell apoptosis is measured
with the Annexin V-FITC/PI apoptosis assay by flow cytometry.
Keywords: coordination polymer, X-ray, nasopharyngeal cancer
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