Platinum(II) complex containing N-(bis(-2,4-dimethoxy-benzyl)carbamothioyl)-4-methylbenzamide ligand: synthesis, crystal structure, Hirshfeld surface analysis, and antimicrobial activity

ЖСХ, т.63, №1, 2022, стр.33

Received: May, 19, 2021
Revised: July, 31, 2021
Accepted for publication: August, 1, 2021
DOI 10.26902/JSC_id85833
Views: 484

¹ Department of Chemistry, Faculty of Arts and Science, Mersin University, Mersin, Turkey

² Advanced Technology Research and Application Center, Mersin University, Mersin, Turkey

³ Department of Molecular Biology and Genetic, Faculty of Arts and Science, Harran University, Sanliurfa, Turkey

⁴ Department of Chemistry, Faculty of Education, Mersin University, Mersin, Turkey

A new complex of Pt(II) bearing N-(bis(2,4-dimethoxybenzyl)carbamothioyl)-4-methylbenzamide ligand is prepared and characterized by ¹H, ¹³C, HMQC, COSY NMR and FTIR spectroscopic techniques. The structure of the complex is determined by single crystal X-ray diffraction. The structural data reveal that the ligands in the cis-conformation attach to the platinum center and the complex has a slightly distorted square-planar geometry. The molecular packing of the complex is mainly supported by the C—H⋯O hydrogen bond, the C—H⋯π interaction, and Pt⋯H nonclassical interactions. The three-dimensional (3D) Hirshfeld surfaces and the associated 2D fingerprint plots of the complex are investigated for the intermolecular hydrogen bonding and non-covalent interactions. In addition, the antimicrobial activity of the free ligand and the Pt(II) complex is evaluated against Gram-positive bacteria (S. aureus, S. pneumoniae, E. faecalis, B. subtilis), Gram-negative bacteria (E. coli, P. aeruginosa), and fungal strains (C. albicans, C. glabrata). The results of this evaluation reveal that ligand is much more active against bacteria than the Pt(II) complex. The highest dose found to be effective against bacterial and fungal strains is evaluated in terms of cytotoxic effects on peripheral blood lymphocytes. It is determined that the 500 mg/mL dose does not cause a cytotoxic effect.

Keywords: crystal structure, platinum complex, antimicrobial activity, benzamide derivatives, Hirshfeld surface analysis

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